Minor/Significance Unknown. Monitor Closely (1)cobicistat will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The recommended dosage of magnesium when using an oxide supplement for treating migraine headaches is between Mechanism: pharmacodynamic synergism. Coadministration with blood pressure lowering agents may increase the risk and severity of hypotension associated with amifostine. Monitor Closely (1)paclitaxel will increase the level or effect of valsartan by Other (see comment). So, if you take 4 capsules, you will get 300 times 4 = 1200 mg Omega-3 daily. Either increases toxicity of the other by Other (see comment). NSAIDs decrease prostaglandin synthesis. Avoid or Use Alternate Drug. Can increase risk of bradycardia. Ca Channel Blockers interfere w/Ach release from prejunctional axon. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (3)valsartan, ketorolac. Comment: Low molecular weight heparins may suppress adrenal aldosterone secretion, which can potentially cause hyperkalemia. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of perindopril by Other (see comment). Monitor Closely (1)verapamil will increase the level or effect of irinotecan by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)valsartan and potassium acid phosphate both increase serum potassium. Avoid or Use Alternate Drug. Either increases toxicity of the other by Other (see comment). The results from an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1; coadministration with OATP1B1 inhibitors may increase valsartan systemic exposure. Use Caution/Monitor. Minor/Significance Unknown. Serious - Use Alternative (1)candesartan, perindopril. Sympathomimetics can antagonize the activity of some antihypertensive agents. 100% FRUITING BODIES & EXTRACTS: Superior Absorption Power Using Highly Concentrated Extracts and 100% Fruiting Bodies. Please confirm that you would like to log out of Medscape. Minor/Significance Unknown. ketorolac intranasal decreases effects of hydralazine by pharmacodynamic antagonism. Monitor Closely (1)verapamil will increase the level or effect of prednisolone by P-glycoprotein (MDR1) efflux transporter. Most Use Caution/Monitor. The frequency and severity of amitriptyline adverse effects (sedation, anticholinergic effects and orthostatic hypotension) may be increased. NSAIDs decrease prostaglandin synthesis. Monitor heart rate in patients taking ivabradine with other negative chronotropes.Serious - Use Alternative (1)verapamil will increase the level or effect of ivabradine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Closely monitor for respiratory depression and sedation and titrate subsequent doses accordingly. Monitor Closely (1)perindopril increases effects of insulin glulisine by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor.verapamil will increase the level or effect of imipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The results from an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1; coadministration with OATP1B1 inhibitors may increase valsartan systemic exposure, Monitor Closely (1)paclitaxel protein bound will increase the level or effect of valsartan by Other (see comment). NSAIDs decrease prostaglandin synthesis. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. Use Caution/Monitor. sodium citrate/citric acid decreases effects of perindopril by unspecified interaction mechanism. verapamil increases effects of succinylcholine by pharmacodynamic synergism. verapamil will increase the level or effect of sirolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. verapamil will increase the level or effect of theophylline by affecting hepatic enzyme CYP1A2 metabolism. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Risk of hypertension. Coadministration may result in a significant decrease in renal function. NSAIDs decrease prostaglandin synthesis. Minor/Significance Unknown. Minor (1)rifampin decreases levels of perindopril by increasing metabolism. Monitor Closely (1)verapamil will increase the level or effect of estrogens esterified by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)hydralazine, dexfenfluramine. Adverse effects of high doses of intravenous alpha lipoic Acid on liver mitochondria. Avoid or Use Alternate Drug. piroxicam, perindopril. Use Caution/Monitor. If the dose of the concomitant CYP3A4 inhibitor cannot be reduced or discontinued, implant removal may be necessary and the patient should then be treated with a buprenorphine dosage form that permits dose adjustments. Additive hypotensive effects. Use Caution/Monitor. doxazosin and verapamil both increase anti-hypertensive channel blocking. Share cases and questions with Physicians on Medscape consult. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Use Caution/Monitor. Modify Therapy/Monitor Closely. Either increases toxicity of the other by Other (see comment). Monitor Closely (1)valsartan increases effects of insulin detemir by unspecified interaction mechanism. Use Caution/Monitor. Use Caution/Monitor. trimagnesium citrate anhydrous, verapamil. hydralazine increases effects of sotalol by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Avoid repeating rimegepant dose within 48 hr if coadministered with a moderate CYP3A4 inhibitor.Serious - Use Alternative (1)verapamil will increase the level or effect of rimegepant by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Use Caution/Monitor. Tell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine.This drug may rarely cause serious (possibly fatal) liver disease. Either increases toxicity of the other by Other (see comment). Monitor Closely (1)perindopril, ibuprofen. STORAGE: Store this medication at room temperature away from light and moisture. Monitor Closely (1)verapamil will increase the level or effect of ivosidenib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Save my name, email, and website in this browser for the next time I comment. Monitor Closely (3)valsartan, indomethacin. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)verapamil, nebivolol. Contraindicated. Minor/Significance Unknown. treprostinil increases effects of hydralazine by pharmacodynamic synergism. perindopril increases effects of insulin NPH by pharmacodynamic synergism. Monitor serum potassium during initiation and dosage adjustment of either finererone or weak CYP3A4 inhibitors. Mechanism: pharmacodynamic synergism. Comment: ACE inhibitors may increase hypoglycemic effect. Monitor Closely (1)levodopa increases effects of verapamil by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may result in a significant decrease in renal function. sulfamethoxazole will increase the level or effect of verapamil by basic (cationic) drug competition for renal tubular clearance. Monitor Closely (1)valsartan increases and bumetanide decreases serum potassium. Use Caution/Monitor. Reviewed in the United States on November 9, 2022. If coadministration of CYP3A4 inhibitors with fentanyl is necessary, monitor patients for respiratory depression and sedation at frequent intervals and consider fentanyl dose adjustments until stable drug effects are achieved. Either increases toxicity of the other by Other (see comment). Either increases effects of the other by pharmacodynamic synergism. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. A daily dose of 2g of the mushroom powder containing 20% beta-glucans provides 400mg of the polysaccharides present in Reishi. Avoid or Use Alternate Drug. verapamil will increase the level or effect of voclosporin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. perindopril, alfuzosin. Modify Therapy/Monitor Closely. marijuana will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)epoprostenol, hydralazine. tecovirimat will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)perindopril increases effects of glyburide by pharmacodynamic synergism. Use Caution/Monitor. Comment: Data suggests that systemic clearance is influenced by modulation of both P-gp and CYP3A4 activities. Avoid or Use Alternate Drug. There is concern that an overdose of ALA may cause a trace element deficiency in patients with diabetes mellitus. Use Caution/Monitor. Risk of hypotension. 120 capsules. lomitapide increases levels of verapamil by P-glycoprotein (MDR1) efflux transporter. verapamil increases levels of indacaterol, inhaled by Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Minor/Significance Unknown. Additionally, beta-glucan has been studied for its role in blood sugar and blood pressure management in people with diabetes and hypertension, respectively. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)choline magnesium trisalicylate, perindopril. verapamil will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. verapamil will increase the level or effect of temsirolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Int J Mol Sci. After discontinuing the CYP3A4 inhibitor for 3 elimination half-lives, may resume previous pexidartinib dose. Use Caution/Monitor. mipomersen, verapamil. Avoid coadministration of pexidartinib with other products know to cause hepatoxicity. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)ibuprofen, perindopril. Monitor Closely (1)verapamil will increase the level or effect of triamcinolone acetonide injectable suspension by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)verapamil will increase the level or effect of alfentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Mushrooms treated with UV lamps can produce even higher amounts of vitamin D. Minor (1)verapamil increases effects of salicylates (non-asa) by unknown mechanism. Use Caution/Monitor. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)verapamil, metoprolol. Either increases toxicity of the other by unspecified interaction mechanism. Minor/Significance Unknown. Additive hypotensive effects.carvedilol increases effects of hydralazine by pharmacodynamic synergism. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Use Caution/Monitor. Coadministration may result in a significant decrease in renal function. amifostine, hydralazine. Risk of fetal compromise if given during pregnancy. Use Caution/Monitor. verapamil, bisoprolol. Monitor Closely (2)verapamil will increase the level or effect of conjugated estrogens by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)hydralazine increases effects of sotalol by pharmacodynamic synergism. . Use Caution/Monitor. Use Caution/Monitor. Increased risk of neurotoxicity. verapamil will increase the level or effect of lumateperone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Within 2 weeks, if signs and symptoms of buprenorphine toxicity or overdose occur and the concomitant CYP3A4 inhibitor cannot be reduced or discontinued, transition the patient back to a buprenorphine formulation that permits dose adjustments. Use Caution/Monitor.valsartan, ibuprofen IV. Use Caution/Monitor. Monitor Closely (1)valsartan increases and furosemide decreases serum potassium. forskolin increases effects of verapamil by pharmacodynamic synergism. Use Caution/Monitor. Minor/Significance Unknown. This product is not intended to diagnose, treat, cure or prevent any disease. Monitor Closely (1)verapamil will increase the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. For best results, take 20-30 min before a meal with an 8oz glass of water or as directed by your healthcare professional. Mechanism: pharmacodynamic antagonism. atazanavir will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.etodolac decreases effects of valsartan by pharmacodynamic antagonism. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. berotralstat will increase the level or effect of verapamil by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)ketoconazole will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Minor (1)verapamil will increase the level or effect of propafenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. The results from an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1; coadministration with OATP1B1 inhibitors may increase valsartan systemic exposure. Avoid or Use Alternate Drug.verapamil will increase the level or effect of erythromycin base by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases levels of the other by Other (see comment). Use Caution/Monitor.verapamil will increase the level or effect of atorvastatin by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)verapamil will increase the level or effect of buprenorphine subdermal implant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If concomitant use unavoidable, reduce the P-gp substrate dosage if recommended in its approved product labeling. Monitor Closely (1)perindopril, ibuprofen IV. Either increases toxicity of the other by Other (see comment). Read More; I Have it Every Night! Use Caution/Monitor. WebMaximum: 16 mg/day PO divided q12hr. Monitor Closely (2)verapamil will increase the level or effect of deflazacort by P-glycoprotein (MDR1) efflux transporter. Trimethoprim decreases urinary potassium excretion. Avoid or Use Alternate Drug. verapamil increases levels of lofepramine by decreasing metabolism. It works by relaxing blood vessels so blood can flow more easily. Consult your doctor for more details.Check your blood pressure and pulse (heart rate) regularly while taking this medication. Minor/Significance Unknown. Coadministration may result in a significant decrease in renal function. Use Caution/Monitor. Use Caution/Monitor. pharmacodynamic antagonism. Either increases effects of the other by pharmacodynamic synergism. Minor (1)shepherd's purse, verapamil. Minor/Significance Unknown. WebTwo-Per-Day Multivitamin. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring. If you log out, you will be required to enter your username and password the next time you visit. Monitor Closely (1)valsartan increases effects of albiglutide by Other (see comment). Avoid or Use Alternate Drug. ketoprofen, perindopril. Use Caution/Monitor. acemetacin decreases effects of perindopril by pharmacodynamic antagonism. Diuretic may be added; careful initial titration required to avoid symptomatic hypotension. Monitor Closely (1)verapamil will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. DOSAGE: 1 - 3g per day; Taken 1 - 3 times daily. rifapentine will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consult your doctor before breast-feeding. Use Caution/Monitor. Use Caution/Monitor. Minor (1)verapamil will increase the level or effect of nitrendipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)valsartan increases and indapamide decreases serum potassium. Additive hypotensive effects. Manufacturer recommends decreasing starting dose of lurasidone to 20 mg/day and maximum daily dose of lurasidone 80 mg when coadministered with moderate CYP3A4 inhibitors. Minor/Significance Unknown. hawthorn increases effects of verapamil by pharmacodynamic synergism. Either increases toxicity of the other by Other (see comment). Otherwise, call a poison control center right away. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Canada residents can call a provincial poison control center. Therapy with carbidopa, given with or without levodopa or carbidopa-levodopa combination products, is started, dosage adjustment of the antihypertensive drug may be required. verapamil increases levels of naldemedine by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Use Caution/Monitor. Observe for possible additive hypotensive effects during concomitant use. Monitor Closely (1)indomethacin decreases effects of hydralazine by pharmacodynamic antagonism. Once P-gp inhibitors are discontinued, increase talazoparib dose (after 3-5 half-lives of the inhibitor) to dose used prior to initiating the P-gp inhibitor(s). verapamil will increase the level or effect of maraviroc by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of hypertension. Avoid or Use Alternate Drug. Use Caution/Monitor. Melatonin Content The melatonin content of an individual spray, pill, or gummy usually ranges from 0.1 milligram to 10 milligrams, with the standard dose being between 1 milligram and 3 milligrams. Minor/Significance Unknown. Comment: Angiotensin II receptor antagonists may enhance hypoglycemic effects of antidiabetic agents by improving insulin sensitivity. verapamil increases levels of crizotinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mechanism: pharmacodynamic antagonism. aspirin decreases effects of hydralazine by pharmacodynamic antagonism. The side effects should wear off over time, but slowly introducing it can help prevent this. Risk of fetal compromise if given during pregnancy. Use Caution/Monitor. Avoid or Use Alternate Drug. 2010diovan-hct-valsartan-hydrochlorothiazide-342341Drugs, encoded search term (valsartan (Diovan)) and valsartan (Diovan), FDA Fast-Tracks Approval of Generic Valsartan in Wake of Recalls, FDA Permits Temporary Distribution of Tainted Losartan, Want to Save a Billion Dollars? lornoxicam decreases effects of perindopril by pharmacodynamic antagonism. Use Caution/Monitor. WebDosage. verapamil increases effects of salsalate by unknown mechanism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)hydralazine will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Serious - Use Alternative (2)verapamil increases levels of bosutinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Do not use a household spoon because you may not get the correct dose. perindopril increases levels of digoxin by unspecified interaction mechanism. Use Caution/Monitor. verapamil decreases levels of oxcarbazepine by increasing metabolism. Use Caution/Monitor. Contraindicated (1)verapamil will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Information suggests voclosporin (an OATP1B1 inhibitor) may increase in the concentration of OATP1B1 substrates is possible. Use Caution/Monitor. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.valsartan, ibuprofen. Minor/Significance Unknown. verapamil, everolimus. The results from an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1; coadministration with OATP1B1 inhibitors may increase valsartan systemic exposure, erythromycin ethylsuccinate will increase the level or effect of valsartan by Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Consult cardiologist if considering treatment. Others use medicinal mushrooms like shiitake and maitake, which are rich in beta-glucan. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Minor/Significance Unknown. Monitor Closely (1)hydralazine increases effects of nebivolol by pharmacodynamic synergism. Monitor Closely (2)verapamil will increase the level or effect of itraconazole by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Use Caution/Monitor. valsartan and noni juice both increase serum potassium. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Consult your doctor for more details. indinavir will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Modify Therapy/Monitor Closely. 2010bidil-isosorbide-dinitrate-hydralazine-342277Drugs, 2010hydra-zide-hydralazine-hydrochlorothiazide-999426Drugs, encoded search term (hydralazine ((hydralazine))) and hydralazine ((hydralazine)), Case Challenge: Woman Presents to Emergency Department With Headache and Hypertension, Heart Failure With Reduced Ejection Fraction: Advances in Management, Updated Heart Failure Guidelines: Time for a Refresh, Medscape Cardiologist Wealth & Debt Report 2021. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Either increases effects of the other by pharmacodynamic synergism. fenoprofen, perindopril. Minor/Significance Unknown. If coadministration is necessary, decrease colchicine dose or frequency as recommended in prescribing information. Monitor Closely (1)indinavir will increase the level or effect of valsartan by Other (see comment). Monitor Closely (1)levoketoconazole will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. See specific ivacaftor-containing product for precise dosage modification.ivacaftor increases levels of verapamil by P-glycoprotein (MDR1) efflux transporter. NSAIDs decrease prostaglandin synthesis. Minor/Significance Unknown. Monitor Closely (1)perindopril, ketorolac. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Modify Therapy/Monitor Closely. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring. metipranolol ophthalmic increases effects of verapamil by pharmacodynamic synergism. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. commonly, these are "non-preferred" brand drugs or specialty Serious - Use Alternative (1)verapamil will increase the level or effect of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)fedratinib will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)verapamil, vortioxetine. Use Caution/Monitor. Amounts and Dosage. Use Caution/Monitor. Consider reducing the dose of verapamil or withdrawing one of the agents.Minor (1)verapamil will increase the level or effect of itraconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Dual blockade of renin-angiotensin system increases risks of hypotension, hyperkalemia, and renal impairment. Use Caution/Monitor. The recommended dosage of magnesium when using an oxide supplement for treating migraine headaches is between Modify Therapy/Monitor Closely. Minor/Significance Unknown. pharmacodynamic antagonism. Use Caution/Monitor. pharmacodynamic antagonism. Use Caution/Monitor. Monitor Closely (3)nelfinavir will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered. Monitor Closely (1)potassium iodide and perindopril both increase serum potassium. Minor/Significance Unknown. BUY FRUITING BODIES (the mushroom cap & stem). Can increase risk of bradycardia. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)fostamatinib will increase the level or effect of verapamil by P-glycoprotein (MDR1) efflux transporter. If it is near the time of the next dose, skip the missed dose. Monitor Closely (1)mefenamic acid decreases effects of hydralazine by pharmacodynamic antagonism. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring. Mechanism: pharmacodynamic synergism. verapamil will increase the level or effect of glecaprevir/pibrentasvir by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. verapamil increases levels of doxepin by decreasing metabolism. Use Caution/Monitor. Sympathomimetics can antagonize the activity of some antihypertensive agents. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown.quinine will increase the level or effect of verapamil by basic (cationic) drug competition for renal tubular clearance. valsartan and carvedilol both increase serum potassium. Use Caution/Monitor. Minor/Significance Unknown. perindopril, phenoxybenzamine. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive hypotensive effects. calcium carbonate decreases effects of perindopril by unspecified interaction mechanism. Exaggerated first dose hypotensive response. Keep taking this medication even if you feel well. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)naproxen, perindopril. Minor (1)verapamil will increase the level or effect of alvimopan by P-glycoprotein (MDR1) efflux transporter. The Reishi mushroom powder dosage is 1-2g/day, and the tincture dose is 1ml/day. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Generally, should not be initiated in patients who are concurrently taking QT prolonging drugs with known arrhythmogenic properties, such as HR-lowering calcium channel blockers (eg, verapamil, diltiazem). Either increases toxicity of the other by Mechanism: pharmacodynamic synergism. Monitor for hypertension with concomitant use. Monitor Closely (1)valsartan increases toxicity of pitavastatin by Other (see comment). Compare formulary status to other drugs in the same class. valsartan increases effects of insulin glargine by unspecified interaction mechanism. Monitor Closely (1)tolfenamic acid decreases effects of hydralazine by pharmacodynamic antagonism. Monitor Closely (1)verapamil increases levels of rifaximin by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)sodium bicarbonate decreases effects of perindopril by unspecified interaction mechanism. verapamil will increase the level or effect of sonidegib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Each drug may cause hypotension. Monitor Closely (1)valsartan and potassium chloride both increase serum potassium. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. The results from an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1; coadministration with OATP1B1 inhibitors may increase valsartan systemic exposure, simvastatin will increase the level or effect of valsartan by Other (see comment). If treatment considered, obtain cardiology consult regarding switching to non-heart-rate lowering drugs or appropriate monitoring for treatment initiation. Modify Therapy/Monitor Closely. Use Caution/Monitor. perindopril, ketorolac intranasal. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. informational and educational purposes only. Adding beta-glucan may cause your blood sugar or blood pressure to drop too low. Use Caution/Monitor. Avoid or Use Alternate Drug. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Monitor Closely (1)verapamil will increase the level or effect of lopinavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. oxaprozin, perindopril. pazopanib will increase the level or effect of valsartan by Other (see comment). Consult your doctor for more details.Lab and/or medical tests (such as kidney function, potassium levels) should be done while you are taking this medication. Use Caution/Monitor. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. verapamil will increase the level or effect of clozapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. valsartan and diflunisal both increase serum potassium. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Avoid or Use Alternate Drug. Use Caution/Monitor.Minor (1)verapamil will increase the level or effect of isradipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tolmetin decreases effects of hydralazine by pharmacodynamic antagonism. Monitor Closely (1)verapamil will increase the level or effect of teniposide by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)propranolol and verapamil both increase anti-hypertensive channel blocking. Avoid or Use Alternate Drug. verapamil will increase the level or effect of fentanyl transdermal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. maitake increases effects of hydralazine by pharmacodynamic synergism. Minor (1)valsartan, entecavir. Can increase risk of bradycardia. If not feasible, avoid use of abametapir. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Avoid or Use Alternate Drug. Use Caution/Monitor. commonly, these are "non-preferred" brand drugs. Minor/Significance Unknown. Avoid or Use Alternate Drug. Monitor Closely (2)stiripentol, verapamil. Modify Therapy/Monitor Closely. Contraindicated. Modify Therapy/Monitor Closely. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Monitor Closely (1)hydralazine will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)verapamil will increase the level or effect of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.Liquid products may contain sugar and/or aspartame. Use Caution/Monitor. Monitor Closely (2)verapamil will increase the level or effect of estradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)verapamil will increase the level or effect of etoposide by P-glycoprotein (MDR1) efflux transporter. hydralazine will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)verapamil will increase the level or effect of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. perindopril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor. Use Caution/Monitor. Finerenone dose adjustment based on current serum potassium concentration. Use Caution/Monitor. Monitor Closely (2)valsartan increases levels of letermovir by decreasing metabolism. Avoid coadministration of moderate CYP3A4 inhibitors with entrectinib, a CYP3A4 substrate. Modify Therapy/Monitor Closely. verapamil will increase the level or effect of atorvastatin by P-glycoprotein (MDR1) efflux transporter. If unable to avoid coadministration with moderate CYP3A4 inhibitors, monitor closely and reduce dose if necessary . Verapamil belongs to a class of drugs known as calcium channel blockers. Mechanism: pharmacodynamic antagonism. Use Caution/Monitor.sotalol, valsartan. Monitor Closely (1)perindopril, insulin degludec/insulin aspart. 2021; 77(6):104311. doi:10.1016/j.jff.2020.104311, Khan K, Jovanovski E, Ho HVT, Marques ACR, et al. Do not exceed recommended dose. NSAIDs decrease prostaglandin synthesis. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Either increases effects of the other by pharmacodynamic synergism. Either increases toxicity of the other by Other (see comment). verapamil will increase the level or effect of lidocaine by affecting hepatic enzyme CYP1A2 metabolism. Either increases toxicity of the other by unspecified interaction mechanism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor.silodosin and verapamil both increase anti-hypertensive channel blocking. hydralazine will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)hydralazine increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Heart Failure (Off-label) WebReishi Mushroom Elixir Mix by Four Sigmatic | Coffee Alternative with Organic Reishi Mushroom Powder, Tulsi, Rose Hips & Mint | Support Stress & Sleep | Decaf, Vegan, Gluten-Free & Keto | 20 Packets 4.5 out of 5 stars 3,492 The results from an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1; coadministration with OATP1B1 inhibitors may increase valsartan systemic exposure. Modify Therapy/Monitor Closely. Coadministration of moderate CYP3A4 inhibitors with midazolam intranasal causes higher midazolam systemic exposure, which may prolong sedation. The results from an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1; coadministration with OATP1B1 inhibitors may increase valsartan systemic exposure, Monitor Closely (2)ritonavir will increase the level or effect of valsartan by Other (see comment). Use Caution/Monitor. Consider decreasing the cilostazol dose to 50 mg twice a day. rifampin will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (2)lapatinib will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. valsartan increases effects of insulin lispro by unspecified interaction mechanism. Avoid or Use Alternate Drug. hydralazine, methylenedioxymethamphetamine. Coadministration may result in a significant decrease in renal function. Use Caution/Monitor.verapamil will increase the level or effect of prednisone by P-glycoprotein (MDR1) efflux transporter. If possible, avoid coadministration or modify dose of OATP1B1/3 substrates coadministered with fostemsavir. Monitor Closely (1)valsartan increases and dopexamine decreases serum potassium. Use Caution/Monitor. Monitor for increased risk of QTc interval prolongation.Serious - Use Alternative (1)ivosidenib will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. midodrine will increase the level or effect of verapamil by basic (cationic) drug competition for renal tubular clearance. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. WebHeres a quick-glance chart for dosage and potency on all of our CBD and delta-9 gummies. Use Caution/Monitor. Serious - Use Alternative (1)nefazodone will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The recipient will receive more details and instructions to access this offer. Beta-glucan is one type of soluble fiber. Risk of hypertension. Effect of interaction is not clear, use caution. Use Caution/Monitor. Consider reducing dose when used concomitantly with lomitapide. How much Reishi per day also highly depends upon the underlying condition for which it is being taken. Sympathomimetics can antagonize the activity of some antihypertensive agents. oxcarbazepine will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Monitor Closely (1)perindopril increases effects of tolazamide by pharmacodynamic synergism. Monitor Closely (1)amifostine, perindopril. While there are many different types of mushrooms, oyster and shiitake mushrooms are good sources of beta-glucan. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Serious - Use Alternative (1)olmesartan, perindopril. This drug is available at a middle level co-pay. Minor/Significance Unknown. Coadministration may result in a significant decrease in renal function. Serious - Use Alternative (1)verapamil will increase the level or effect of topotecan by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)trimagnesium citrate anhydrous, verapamil. , Reviewed in the United States on August 17, 2021. Exaggerated first dose hypotensive response. Information suggests voclosporin (an OATP1B1 inhibitor) may increase in the concentration of OATP1B1 substrates is possible. Methylphenidate may diminish antihypertensive effects. Increases risk for hypoglycemia and lactic acidosis. Monitor Closely (1)calcium gluconate decreases effects of verapamil by pharmacodynamic antagonism. Comment: Velpatasvir inhibits OATP1B1, OATP1B3, and OATP2B1 transporters. Coadministration with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of either entecavir or the coadministered drug. Use Caution/Monitor. Modify Therapy/Monitor Closely. Read Doing so can release all of the drug at once and may increase your risk of side effects.If you have trouble swallowing the capsule, you may open the capsule and carefully sprinkle its contents on a spoonful of soft, cool applesauce just before you take it. Mechanism: pharmacodynamic synergism. NVAF: No dose reduction recommended. Avoid or Use Alternate Drug. Concomitant use of a moderate 3A4 inhibitor such as verapamil may significantly increase the plasma concentrations of everolimus following oral administration. valsartan and acebutolol both increase serum potassium. Use Caution/Monitor. Avoid or Use Alternate Drug. Comment: ACE inhibitors may increase hypoglycemic effect. Monitor Closely (1)diclofenac decreases effects of hydralazine by pharmacodynamic antagonism. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Mechanism: pharmacodynamic synergism. Keep taking this medication even if you feel well. Consider reducing the cannabidiol dose when coadministered with a moderate CYP3A4 inhibitor. Properly discard this product when it is expired or no longer needed. tizanidine increases effects of valsartan by pharmacodynamic synergism. Neutralizes free radicals & oxidative damage. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada). GFR 30 mL/min/1.73m 2: Tablets and oral suspension are not substitutable on a mg-per-mg basis; systemic exposure (AUC) is 60% higher with suspension compared with tablets reishi. Use Caution/Monitor. This medication is also used to prevent heart attacks in people with a certain type of heart disease (stable coronary artery disease). ibuprofen IV, perindopril. Minor (1)verapamil increases effects of cisatracurium by pharmacodynamic synergism. Minor/Significance Unknown. Use Caution/Monitor. Contraindicated. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. acebutolol and verapamil both increase anti-hypertensive channel blocking. Monitor Closely (1)hydralazine, methamphetamine. Monitor Closely (2)verapamil will increase the level or effect of mifepristone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. verapamil increases effects of onabotulinumtoxinA by pharmacodynamic synergism. The largest meta-analysis assessed 59 clinical trials comparing an oat supplement intervention to a control group. Can increase risk of bradycardia. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Use Caution/Monitor. stiripentol, verapamil. Use Caution/Monitor. Dosage: How Much Beta-Glucan Should I Take? Minor/Significance Unknown. Use Caution/Monitor. See drug monograph for specific dosage modification. perindopril increases effects of insulin glulisine by pharmacodynamic synergism. Most Monitor more closely for signs of venetoclax toxicities.verapamil will increase the level or effect of venetoclax by P-glycoprotein (MDR1) efflux transporter. If concomitant use is necessary, may require less frequent oliceridine dosing. Journal of Functional Foods. Monitor Closely (1)bosentan will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)perindopril increases effects of insulin lispro by pharmacodynamic synergism. Contact your health-care provider immediately if you suspect that you have a medical problem. verapamil will increase the level or effect of estrogens esterified by affecting hepatic/intestinal enzyme CYP3A4 metabolism. May inhibit organic anion transporter polypeptides; decrease dose of angiotensin receptor blockers and monitor patients for signs and symptoms of hypotension and/or worsening renal function; if such events occur, consider further dose reduction of angiotensin receptor blocker or switching to alternative to angiotensin receptor blocker Minor (1)ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will increase the level or effect of valsartan by decreasing elimination. Overall, fiber was found to reduce systolic and diastolic blood pressure. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.valsartan, salsalate. Use Caution/Monitor. Avoid or Use Alternate Drug. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Modify Therapy/Monitor Closely. Monitor Closely (1)crofelemer increases levels of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. On my first bottle so a bit early to be sure but they do see to be helping with focus and energy. Minor/Significance Unknown. Monitor Closely (1)valsartan and triamterene both increase serum potassium. Monitor Closely (1)valsartan, bretylium. Use Caution/Monitor. Minor (1)verapamil increases effects of choline magnesium trisalicylate by unknown mechanism. Monitor Closely (1)griseofulvin will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)verapamil will increase the level or effect of tamoxifen by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Buy Naturealm Sacred 7 - Mushroom Extract Powder 8 oz - Chaga, Cordyceps, Lion's Mane, Maitake, Reishi, Shiitake & Turkey Tail - Organic Herbal Nootropic Supplement - Focus, Energy & Mental Performance on Consider decreasing dosage of antihypertensive agent. Coadministration with blood pressure lowering agents may increase the risk and severity of hypotension associated with amifostine. Follow your doctor's instructions carefully.Take this medication regularly to get the most benefit from it. Your dose may need to be gradually decreased.Tell your doctor if your condition does not get better or if it gets worse (your blood pressure readings remain high or increase). Monitor Closely (2)hydralazine increases effects of carvedilol by pharmacodynamic synergism. Use Caution/Monitor. Coadministration with blood pressure lowering agents may increase the risk and severity of hypotension associated with amifostine. Monitor Closely (1)hydralazine increases effects of esmolol by pharmacodynamic synergism. Minor/Significance Unknown. Observe for possible additive hypotensive effects during concomitant use. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Minor/Significance Unknown. Perindopril may harm an unborn baby. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)saquinavir will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. BOOST IMMUNE SYSTEM: Helps strengthen your immune system with our potent mushroom extract formula year-round. Comment: With concomitant use of mTOR inhibitors, consider appropriate dose reductions of both medications. Coadministration of verapamil and cyclosporine may increase plasma concentrations of either drugs. Avoid coadministration of lemborexant with moderate or strong CYP3A inhibitors. Think of reishi as natures Xanax. Additive hypotensive effects. Adjust finererone dosage as needed. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Either increases effects of the other by pharmacodynamic synergism. valsartan increases effects of insulin glulisine by unspecified interaction mechanism. NSAIDs decrease prostaglandin synthesis. Remember that alternative medicine should not be used as a substitute for standard care. Minor (1)verapamil will increase the level or effect of cevimeline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Most people don't get enough fiber in their diet. Monitor for increased risk of QTc interval prolongation. Observe for possible additive hypotensive effects during concomitant use. Monitor for increased bradycardia, hypotension, or dizziness. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Use Caution/Monitor. digoxin will increase the level or effect of verapamil by basic (cationic) drug competition for renal tubular clearance. Use Caution/Monitor.amiodarone, verapamil. Monitor Closely (1)azithromycin will increase the level or effect of verapamil by P-glycoprotein (MDR1) efflux transporter. . valsartan and ibuprofen both increase serum potassium. Comment: OATP1B1 inhibitors may increase risk of myopathy. Modify Therapy/Monitor Closely. Monitor Closely (1)hydralazine, yohimbine. Use Caution/Monitor. Between 1 - 3 g per day. Either increases effects of the other by pharmacodynamic synergism. If coadministration is necessary, decrease colchicine dose or frequency as recommended in prescribing information. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. (Sustained release form of verapamil). voclosporin will increase the level or effect of valsartan by Other (see comment). Monitor Closely (1)dofetilide will increase the level or effect of verapamil by basic (cationic) drug competition for renal tubular clearance. Monitor Closely (1)valsartan and aspirin rectal both increase serum potassium. Use Caution/Monitor. Monitor Closely (1)bosutinib increases levels of verapamil by P-glycoprotein (MDR1) efflux transporter. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Avoid or Use Alternate Drug. Monitor for hypotension or muscle weakness in patients receiving calcium channel blockers with elevated serum magnesium concentrations. hydralazine increases effects of nebivolol by pharmacodynamic synergism. Contraindicated. Avoid or Use Alternate Drug. Amounts and Dosage. Minor/Significance Unknown. valsartan increases and methyclothiazide decreases serum potassium. Use Caution/Monitor. Additive hypotensive effects. In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of ARBS with drugs that affect RAAS may increase the risk of renal impairment (including acute renal failure) and cause loss of antihypertensive effect. Contraindicated (1)verapamil increases levels of pimozide by decreasing metabolism. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. verapamil increases toxicity of doxorubicin liposomal by decreasing metabolism. Minor/Significance Unknown. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. NSAIDs decrease prostaglandin synthesis. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Ca Channel Blockers interfere w/Ach release from prejunctional axon. Either increases toxicity of the other by pharmacodynamic synergism. Med Clin North Am. Avoid or Use Alternate Drug. Risk of hyperkalemia. Minor/Significance Unknown. verapamil will increase the level or effect of clozapine by affecting hepatic enzyme CYP1A2 metabolism. Plasma concentrations and pharmacologic or toxic effects of eplerenone may be increased by verapamil. valsartan and nebivolol both increase serum potassium. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring. Monitor Closely (2)metoprolol, valsartan. Monitor Closely (1)perindopril, diflunisal. 2014. Use Caution/Monitor. Monitor heart rate in patients receiving concomitant verapamil and clonidine.verapamil, clonidine. pharmacodynamic antagonism. Monitor Closely (1)ketorolac decreases effects of hydralazine by pharmacodynamic antagonism. Comment: Coadministration increases risk of angioedema. No adverse effects reported in research studies. Modify Therapy/Monitor Closely. dofetilide will increase the level or effect of verapamil by basic (cationic) drug competition for renal tubular clearance. Modify Therapy/Monitor Closely. Use Caution/Monitor. Minor/Significance Unknown. Risk of hypertension. Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Monitor Closely (1)verapamil will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. NSAIDs decrease prostaglandin synthesis. sacubitril/valsartan, perindopril. Monitor for toxicities of the P-gp substrate drug that may require dosage reduction when given concurrently with fostamatinib. Monitor Closely (2)bisoprolol, valsartan. Use Caution/Monitor. Monitor Closely (1)valsartan and salicylates (non-asa) both increase serum potassium. Use Caution/Monitor. nicardipine and verapamil both increase anti-hypertensive channel blocking. Monitor patients for changes in glycemic control. verapamil will increase the level or effect of guanfacine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. Avoid or Use Alternate Drug. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring. If a CYP3A4 inhibitor is discontinued in a patient who has been stabilized on buprenorphine, monitor the patient for withdrawal. Use Caution/Monitor.fenoprofen decreases effects of valsartan by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis. Sinus bradycardia resulting in hospitalization and pacemaker insertion has been reported in association with the use of clonidine concurrently with verapamil. Minor/Significance Unknown. valsartan and acebutolol both increase serum potassium. Use Caution/Monitor. Use Caution/Monitor.etravirine will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. valsartan will increase the level or effect of digoxin by decreasing renal clearance. Use Caution/Monitor. Monitor Closely (1)perindopril increases effects of insulin glargine by pharmacodynamic synergism. verapamil increases levels of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)valsartan increases effects of liraglutide by Other (see comment). perindopril, indomethacin. Use Caution/Monitor. Minor/Significance Unknown. Serious - Use Alternative (2)verapamil will increase the level or effect of venetoclax by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)verapamil will increase the level or effect of antipyrine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.verapamil will increase the level or effect of estradiol by P-glycoprotein (MDR1) efflux transporter. View the formulary and any restrictions for each plan. Either decreases toxicity of the other by unknown mechanism. Use Caution/Monitor. Monitor Closely (1)perindopril, choline magnesium trisalicylate. Minor/Significance Unknown. verapamil will increase the level or effect of paclitaxel protein bound by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). aceclofenac decreases effects of perindopril by pharmacodynamic antagonism. Use Caution/Monitor. IDM Members' meetings for 2022 will be held from 12h45 to 14h30.A zoom link or venue to be sent out before the time.. Wednesday 16 February; Wednesday 11 May; Wednesday 10 August; Wednesday 09 November Use Caution/Monitor. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Serious - Use Alternative (2)verapamil, temsirolimus. Mechanism: pharmacodynamic synergism. Either increases toxicity of the other by pharmacodynamic synergism. Monitor Closely (1)verapamil will increase the level or effect of imatinib by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (2)clonidine, verapamil. This drug is available at a middle level co-pay. Controlled studies in pregnant women show no evidence of fetal risk. Avoid use with drugs that are both P-gp and strong CYP3A4 inhibitors. 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