2011 May 15;29(7):644-52. Differential modulation of TREM2 protein during postnatal brain development in mice. Embryonic microglia derive from primitive macrophages and are replaced by cmyb-dependent definitive microglia in zebrafish. In this session, sponsored by the ASBMBs Maximizing Opportunities for Scientific and Academic Independent Careers program, or MOSAIC, panelists Cirleen DeBlaere of Georgia State University, Carlota Ocampo of Trinity Washington University and Stephen Quaye of Ohio State University will lead insightful discussions pertaining to the intersectionality of race and mental health of STEM trainees. GCB brings together scientists, engineers, physicians and sociologists passionate about interdisciplinary research to explore big questions in genomics and computational biology. Intuitively, this classification system is similar to the concept of neuronal cell types, where neurons cluster into distinct subtypes based on their gene expression or neuroanatomy. - Different plots using R (heatmap & volcano plots) ; Subramanian Karur, M.A. The focus of this workshop will be on nuclear pore proteins as guardians of mRNA export and their role in the selectivity of RNA export in health and disease. Microglial cells display a profusion of morphologies that have fascinated researchers since the early days of Ro-Hortega. This session will cover new mechanisms in intra- and intercellular communication that have been uncovered through quantitative and structural biology. Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease. Microglial states depend on intrinsic determinants (such as species, ontogeny, sex, or genetic background) as well as the specific context they inhabit, including age, spatial location, and environmental factors (such as nutrition, microbiota, pathogens, drugs, etc.). STING signaling compensates for mutation burden-low tumors to stimulate the immune response. ; Sonia Vallet; Christina Chittilappilly; Theo Pirich; Judith Lind; Osman Aksoy; Vincent Sunder-Plassmann; Klaus Hackner; Elisabeth Zwickl-Traxler; Peter Errhalt; Martin Pecherstorfer; Klaus Podar, Biomarkers;Clinical study;Coinhibition;Immune toxicity, Relationships between irAEs and checkpoint inhibitor response in RADIOHEAD: a large prospective pan-tumor cohort of standard-of-care patients with clinical annotation, molecular and immune profiling, Anastasia Lucas; Samantha I. Liang, PhD; Diane Da Silva; Arabella Young, PhD; Zoe Quandt; Silvia Boffo, PhD; Lisa M. Salvador; Lacey J. Padrn, PhD; Mark S. Anderson, MD, PhD; Marshall Thompson, PhD; Christine N. Spencer, PhD, Checkpoint blockade;Epidemiology;Solid tumors, Single Cell Immunologic Dissection of Checkpoint Inhibitor Hepatitis and Autoimmune Hepatitis Reveals Insights into Immune Tolerance in the Human Liver, Molly Thomas, MD PhD; Tos Chan; Neal P. Smith; Marc Sherman; Swetha Ramesh; Alice Tirard; John McGuire; Mazen Nasrallah, MD; Kasidet Manakongtreecheep; Jessica Tantivit; Leyre Zubiri, MD; Dejan Juric, MD; Ryan J. Sullivan, MD; Genevieve Boland, MD PhD; Georg Lauer, MD PhD; Nir Hacohen, PhD; Kerry L. Reynolds, MD; Chloe Villani, PhD, Antigen presenting cells;Autoimmunity;Checkpoint blockade;Immune tolerance;Immune toxicity;Inflammation;Monocyte/Macrophage;Systems biology;T cell;T cell lineages, PBMC humanized mouse model with clinical relevance in assessing the safety profile of 4-1BB agonists utomilumab and urelumab, Destanie Rose, PhD; Wenqian He, PhD; Bernard S. Buetow, PhD; Allison Vitsky, DVM; Maggie Lui, PhD; Jiwon Yang, PhD; Guoxiang Yang, PhD; James G. Keck; Bart Jessen, PhD, Cytokine;Immune toxicity;Inflammation;T cell, Real world experience of immunotherapy in an elderly trial-ineligible cohort of patients with advanced cutaneous squamous cell carcinoma, Luke S. Mclean, MBBS (Hons); Annette M. Lim; Angela Pizzolla, PhD; Benjamin Solomon; Danny Rischin, MBBS, MD, Comparative safety and effectiveness of IL6R Inhibitors, TNF inhibitors and Methotrexate for the treatment of Immune Checkpoint Inhibitor-associated arthritis, Anne R. Bass, MD; Noha Abdel-Wahab, MD, PhD; Jeffrey Sparks; Pankti Reid, MD, MPH; Cassandra Calabrese; Deanna Jannat-Khah, DrPH, MSPH; Divya Rajesh; Nilasha Ghosh, MD; Komal Mushtak, MD; Farah Al Haj, MD; Lydia Gedmintas, MD, MPH; Adewunmi Falohun, DO; Lindsey Macfarlane, MD; Michael Postow, MD; Adi Diab; Ami Shah, MD; Clifton Bingham, III, MD; Karmela K. Chan, MD; Laura Cappelli, MD, Antibody;Autoimmunity;Checkpoint blockade;Immune suppression;Immune toxicity;Inflammation, Increased concentrations of S100B and neurofilament light chain in serum indicate checkpoint inhibitor-induced CNS inflammation, Sara Bjursten, MD; Ankur Pandita, MD; Zhiyuan Zhao, MD, PhD; Joel Simrn, MD; Henrik Zetterberg, MD, PhD; Anna Rudin, MD, PhD; Lars Ny, MD, PhD; Max Levin, MD PhD, Biomarkers;Checkpoint blockade;Immune toxicity, Elevated serum TNF- is a candidate prognostic biomarker for immune checkpoint inhibitor myocarditis, Rebecca Caldwell; Gaspar Pina; Praise Oderinde; Abdelrahman Ali; Jensen Garrett; Bilal A. Siddiqui, MD; Sumit K. Subudhi, MD, PhD; Cezar Iliescu; Syed Wamique Yusuf; Efstratios Koutroumpakis; Ihab Hamzeh; Shaden Khalaf; Anita Deswal; Nicolas L. Palaskas, MD, Dermatologic immune related adverse event disease definitions: a multi-institutional Delphi consensus project presented on behalf of the oncodermatology working group, Steven T. Chen, MD, MPH, MHPEd; Nicole LeBoeuf, MD; Kerry L. Reynolds, MD; Yevgeniy R. Semenov, MD, Autoimmunity;Checkpoint blockade;Immune toxicity, A set of easy and stringent criteria to identify Immune-related adverse events (IrAE Scoring System, ISS) improves correlation with outcome in a phase 1-2 trial population, Luca Mazzarella, MD, PhD; Federica Giugliano; Eleonora Nicolo'; Edoardo Crimini; Jacopo Uliano; Chiara Corti; Paolo d'Amico; Pamela Trillo Aliaga; Carmine Valenza; Matteo Repetto; Gabriele Antonarelli; Liliana Ascione; Grazia Vivanet; Pierpaolo Berton Giachetti; Ida Minchella; Carmen Belli, MD, PhD; Angela Esposito; Marzia Locatelli; Carmen Criscitiello; Giuseppe Curigliano, MD, PhD, Biomarkers;Checkpoint blockade;Clinical study;Clinical trial;Immune toxicity;Solid tumors, Vedolizumab plus anti-PD1 antibody in advanced melanoma patients with inflammatory enterocolitis, Asad Javed, MBBS; Michele Freesmeier, MPAS, PA-C; Yousef Zakharia, MD; Mohammed M. Milhem, MBBS, Toxicity profiles of weight-based 2-weekly and flat-dose 4-weekly nivolumab regimen - a real-world Australian centre experience, Sang Yoon Kim, MB ChB; Prajwol Shrestha; Andre van der Westhuizen, The Effect of Immunosuppression During Anti-PD-1 Treatment for Stage III Melanoma, Andrew D. Knight, MD; John M. Kirkwood, MD; Lilit Karapetyan; Xi Yang, MD; Sneha Rajendran, MD; Na Bo; Hong Wang, PhD; Cindy Sander, BS, Checkpoint blockade;Clinical study;Immune adjuvant;Immune suppression;Immune toxicity;Solid tumors, Increased risk of cutaneous immune-related adverse events in patients treated with Talimogene Laherparepvec and immune checkpoint inhibitors: a multi-institutional cohort study, Bonnie W. Leung, BS; Guihong Wan, PhD; Nga Nguyen, MD, MPH; Shijia Zhang, MBI; Wenxin Chen, BS; Sonia Cohen, MD, PhD; Genevieve Boland, MD PhD; Ryan J. Sullivan, MD; Riley Fadden, NP; Howard Kaufman, MD; Shawn Kwatra, MD; Nicole LeBoeuf, MD; Yevgeniy R. Semenov, MD. Circulating lipid profile as a prognostic factor in patients with advanced solid tumors treated with immune checkpoint inhibitors. Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain. come from the School of Medicine, Pratt School of Engineering, Nicholas School of the Environment, and the Trinity College of Arts and Sciences, apply modeling and experimentation to understand and design complex biological systems using a wide range of approaches and model systems, develop innovative methods to generate unique data sets and formulate novel approaches to analyze them, design and disseminate next-generation technologies and best practices for research. King, Ph.D.; Benjamin J. Zeskind, PhD, MBA, Increased activity of the ATX/LPA axis diminishes CD8+ T cell cytotoxicity via LPAR5 signaling, driving immune checkpoint blockade resistance in non-small cell lung cancer, Jessica M. Konen, PhD; B. Leticia Rodriguez; Haoyi Wu; Jared J. Fradette; Lixia Diao; Jing Wang, PhD; Don L. Gibbons, MD, PhD, Checkpoint blockade;Immune suppression;Solid tumors;T cell;Targeted therapy;Tumor evasion;Tumor infiltrating lymphocytes (TILs). Hendrickx, PhD; Davide Bedognetti, MD, PhD; Peter Kuppen, Immunoscore;T cell;Tumor infiltrating lymphocytes (TILs), Myeloid and T cell subsets defined in bladder cancer using single-cell RNA sequencing and paired protein profiling, Viktor Sincic, MSc; Ashfaq Ali, PhD; Alar Aab, PhD; Thoas Fioretos, PhD; Carl Borrebaeck, PhD; Fredrik Liedberg, PhD; Kristina Lundberg, PhD, Antigen presenting cells;Dendritic cell;Gene expression;Immune suppression;Monocyte/Macrophage;Myeloid cells;NK/NKT cell;Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs), Immune cell subtypes associated with the level of tumor-infiltrating lymphocytes in breast tumor microenvironment, Su Min Cha; Jeong-Han Seo, PhD candidate; Jung-Wook Park, PhD candidate; Hee Jae Lee, PhD; Hee Jin Lee, ZG033, a novel CD137 agonist, induces superior anti-tumor activity without hepatotoxicity rely on Fc-mediated crosslinking, Liansheng Cheng; Wenting Liu; Dayan Zhang; Xiaoli Zeng; Guodong Shen, Antibody;Costimulation;NK/NKT cell;Solid tumors;Tumor infiltrating lymphocytes (TILs), HBM7008, a first-in-class bispecific antibody targeting both B7-H4 and 4-1BB, exhibits robust anti-tumor immunity and low toxicity through B7-H4-directed 4-1BB activation, Bing Huang, Ms., Ph.D.; Fangfang Du; Xiaocheng Lv; Jianxun Zhao; Fei Chen; Zailian Lu; Yang Zhang; Victor Chen; Xin Gan; Jiuqiao Zhao; Yun He; Xiaodong Wu, PhD; Yiping Rong, Bispecifics;Checkpoint blockade;Costimulation;T cell;Tumor infiltrating lymphocytes (TILs), YH32364 (ABL104), a novel EGFR/4-1BB bispecific antibody exhibits potent antitumor efficacy with an excellent safety profile, Eunjung Lee, PhD; Hyejin Chung; Yangsoon Lee; Young Bong Park; Eun-Jung Lee; Hyunmo Koo; Mikyeong Ju; Ju Young Park; Sujin Ahn; Junhwan Kim; Kyeongsu Park; Wonjun Son; Jaehyun Eom; Hanbyul Lee; Jaeho Jung; Jonghwa Won; Se-Woong Oh, Bispecifics;T cell;Targeted therapy;Tumor infiltrating lymphocytes (TILs). perform quality checks (QC) on single-cell data. Octavia Bane, PhD; Enamul Bhuiyan, PhD; Paul Kennedy, PhD; Muhammed Shareef, MD; Pauline Hamon, PhD; Mark Buckup, PhD; Sacha Gnjatic, PhD; Stefanie Hectors, PhD; Hung Kam Cheung; Elizabeth Miller; Maria Isabel Fiel, MD; Stephen Ward; Myron E. Schwartz, MD; Thomas U. Marron, MD, PhD; Miriam Merad, MD, PhD; Bachir Taouli, MD, MSHA, Biomarkers;Checkpoint blockade;Immune adjuvant;Solid tumors;T cell, PRELIMINARY RESULTS OF A PILOT STUDY OF INTRATUMORAL INJECTION OF AUTOLOGOUS DENDRITIC CELLS AFTER HIGH-DOSE CONFORMAL EXTERNAL BEAM RADIOTHERAPY IN UNRESECTABLE PRIMARY LIVER CANCERS. Bioinformatics;Immunoscore;MDSC;Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs), Body mass index (BMI) and serum albumin level as a predictor of survival outcomes in advanced-stage melanoma patients treated with anti-PD1 therapy, Yusuf R. Mohamoud; Yeonhee Park; Dahlia H. Tesfamichael; Vincent Pozorski; Vincent T. Ma, MD, Biomarkers;Checkpoint blockade;Clinical study, Sensitivity and concordance of CD274 expression by RNA sequencing (RNA-seq) in comparison with three PD-L1 immunohistochemistry methods in head and neck squamous cell carcinoma (HNSCC), Mary K. Nesline; Sarabjot Pabla, Ph.D.; Jeffrey Conroy, BS; Paul DePietro, PhD; Shengle Zhang; Roger Klein; Achyut Bhagelu, PhD; Rebecca Previs; Prasanth Reddy; Shakti Ramkissoon; Eric Severson, Single cell FFPE and spatial transcriptomic profiling of an invasive ductal carcinoma enhances cellular and spatial insights, Ryan Stott, PhD; Jawad Abousoud; Stephen Williams, PhD; Shamoni Maheshwari, PhD; Valeria Giangarra, PhD; Sarah Taylor, PhD; Andrew Kohlway, PhD, Bioinformatics;Gene expression;RNA;Solid tumors, CAR-T Engager proteins optimize anti-CD19 CAR-T cell therapies for lymphoma, Paul D. Rennert, PhD; Lihe Su, PhD; Lan Wu, PhD; Roy R. Lobb, PhD; Christine Ambrose, PhD, Adoptive immunotherapy;CAR T cells;Leukemia/Lymphoma;T cell, Immune Activation by Antigen-specific T cells Elicited in Patients Receiving Standard Therapy for Pediatric Solid Tumors, Jillian P. Smith, MD; Amy Hont, MD; Catherine Bollard, MD, Adoptive immunotherapy;Pediatric tumors;Solid tumors;T cell. ; Geona Kim, M.S. Haas BJ, et al. Heterozygous mutations, particularly in the kinase domain of. Tonneau, MD; Kim Phan; Ccile Low-Kam; Francis Dutil; Suzanne Kazandjian; Davy Vanderweyen; Justin Panasci; Julie Malo; Franois Coulombe; Arielle Elkrief; Wiam Belkad; Lisa Di Jorio; Michle Orain; Nicole Bouchard; Thierry Muanza; Kam Kafi; Florent Chandelier; Philippe Joubert; Bertrand Routy, Conditional bispecific T cell engager design and dosing optimization via mechanistic modeling, Jess Q. Wu, PhD; Michael Vilkhovoy, PhD; Sara Shum, PhD; Johara Chouitar, PhD; Patrick LeRoy; Leticia Fridman; Eilene Kwok; Glendon Wu; Matyas Ecsedi, MD, PhD; Antara Banerjee, Ph.D.; Dean C. Bottino, PhD, Bispecifics;Solid tumors;Systems biology;T cell;Tumor microenvironment, Spatial Analysis of the Tumor Microenvironment using Machine Learning-Enabled Integrated Morphology-Transcriptomic Cell Phenotypes, Wei Yan; Nga H. Luong; Jeffrey C. Lim; Yuezhen Xue; Abu Bakr Azam, M.Engg; Joe Poh Sheng P. Yeong, MD, PhD; Mai Chan Lau; Yiyu Cai, PhD, B cell;Bioinformatics;Gene expression;T cell;Tumor microenvironment, Prediction of Best Response for NSCLC Patients Receiving Immunotherapy by Machine Learning Models. Availability and Restrictions The following versions of Trinity are available on OSC clusters: * Current default version You can use module spider trinityrnaseq to view available modules for a given machine. PhD; Mahmoud Abu-Amna, MD; Abed Agbarya, MD; Rivka Katzenelson, MD; Michal Lotem, MD. ; Amelie Muth; Michael Von Bergwelt-Baildon, MD, PhD; Veit Bcklein, Bispecifics;Checkpoint blockade;Leukemia/Lymphoma;T cell, Triple therapy (binimetinib, bevacizumab, pembrolizumab) modulates the tumor immune microenvironment in microsatellite stable colorectal cancer PDXs in a humanized mice model, Julie Lang, PhD; Adrian Dominquez; Matthew Lewis, MS; Sarah J. Hartmann, MS; Jordi M. Lanis, PhD; Hannah Strassburger; Wells A. Messersmith, MD, FACP, FASCO; S. Lindsey Davis, MD; Alexis D. Leal, MD; Sunnie Kim, MD; Kimberly R. Jordan, PhD; Tyler Friedrich, MD; Christopher Lieu, MD; Todd Pitts, PhD, Checkpoint blockade;Immune contexture;Immune monitoring;Immune suppression;Regulatory T cell (Treg cell);Solid tumors;T cell lineages;Targeted therapy;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, BET inhibitors synergize with anti-PD1 by enhancing TCF7 accessibility in leukemia-derived terminally exhausted CD8+ T cells, Kyle Romine, PhD; Kevin MacPherson; Hyun-jun Cho; Yoko Kosaka, PhD; Patrick Flynn; Kaelan H. Byrd; Jesse L. Coy; Matthew T. Newman; Jamie Scott; Andrew C. Adey; Evan F. Lind, PhD, Checkpoint blockade;Immune suppression;Leukemia/Lymphoma;T cell. The degradation of misfolded proteins in the ER, Post-Translational control of HMG CoA reductase, the rate-limiting enzyme of cholesterol synthesis, Signaling principles, signal decoding and integration revealed by stress, The role of rhomboid pseudoproteases in ERADicating misfolded membrane substrates, Seeing equity in courses from data to faculty learning communities, Creative strategies to perform an inclusive faculty search (Part I), Creative strategies to perform an inclusive faculty search (Part II), Listening to and partnering with students to build inclusive STEM communities, Structural basis for signaling by the HER3 pseudokinase, Tracing copper utilization by kinase signal transduction pathways: Implications for cancer cell processes, Regulation of metabolic network function with enzyme expression, Identifying toxic metabolites and their roles in disease, Transcriptionalregulation of primary and specialized metabolism, Interorgan crosstalk and metabolism regulation in Drosophila, Regulation of PIP2 homeostasis at ER-plasma membrane contacts by Nir proteins, Roles for inter-organelle contacts in organizing metabolism, Systematic analysis of membrane contact sites, Novel pathways of intracellular membrane lipid transport and neurodegenerative diseases, Sponsored by the ASBMB Public Affairs Advisory Committee, The phase of fat: mechanisms and physiology of lipid storage, Progress toward understanding protein control of reaction outcome in the diverse reactivity of iron (II) and 2-oxoglutarate-dependent oxygenases, The evolution and mechanism of GPCR proton sensing, Structures and kinetics of Thermotoga maritima MetY reveal new insights into the predominant sulfurylation enzyme of bacterial methionine biosynthesis, SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis, Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template, Snapshots of lipid synthesis and fat storage, Transformations of phosphonates by non-heme iron-dependent oxygenases, Structural remodelling of the carbonphosphorus enzymatic machinery by a dual ATP-binding cassette module, Mechanism and evolution of [4+2] cyclases in monoterpene indole alkaloid biosynthesis, Structurally investigating a niche pathway for chemical reversal of proline hydroxylation in the pathogen Clostridioides difficile, Conformationally altered hyaluronan mitigates the symptoms of Parkinson disease in mice, Exploring new bacterialfungal interactions: The role of mannan degradation in Streptococci growth, OTX2's dual mode of degradation is regulated by O-GlcNAcylation, Maternal Zika virus infection alters offspring hippocampal glycan sulfation patterns in nonhuman primates, A seleniumiron axis dictates cancer cell sensitivity to pharmacologic ascorbate, A tandem activity-based sensing and labeling strategy enables imaging of transcellular hydrogen peroxide signaling, Ketones improve the mitochondrial coupling efficiency of brown adipocytes, An organism-wide atlas of tissue crosstalk in physical activity, Structure of a pathologic amyloid nucleus determined by rational genetic deconstruction of an intracellular nucleation barrier, Interplay between TPR nucleoporin and TREX-2 complex in mRNA export, Engineered nuclear import receptor karyopherin-2 chaperones aberrant phase transitions of disease-associated cargo, Proteasome localization is regulated through mitochondrial respiration and kinase signaling, Identification of signaling pathways and phase separating domains that drive cajal body formation, Self-assembling long coiled-coil proteins driving the formation of a nanoscale cylindrical architecture at human centrosomes, Client specificity of an ATP-independent chaperone is regulated by a temperature sensitive switch, Investigating mitochondrial dysfunction in Barth syndrome, First-in-class deubiquitylase inhibitors reveal new enzyme conformations, Non-canonical recruitment of PKA catalytic subunits to RI-driven biomolecular condensates, The plastoglobule-localized AtABC1K6 is a Mn2+-dependent protein kinase necessary for timely transition to reproductive growth, The role of substrate deformation in context-dependent non-CG DNA methylation, Epigenetics: A gatekeeper to DNA amplification and replication control, Rotational dynamics of the MLL complex on nucleosome and its implication in heterogeneity of the epigenetic landscape, Transcriptional regulation via strand displacement DNA repair in G-quadruplexes, ATG9 vesicles are incorporated into nascent autophagosome membranes, From flat to bulb novel insights in caveolae membrane curvature, Membrane phosphoinositides stabilize GPCR-arrestin complexes and provide temporal control of complex assembly and dynamics, Molecular investigation of the TTD and PHD histone binding domains of the epigenetic regulator UHRF2, Protection of telomeres 1b modulates cellular ROS and chromatin structure in Arabidopsis thaliana, Transcriptome and regulome signatures of multiple myeloma induced by bone marrow stromal cells, Structural and biophysical characterization of plasmodium falciparum bromodomain protein 1, Divalent cation driven liquid-liquid phase separation of disordered acidic proteins, Imaging mRNAs with corrected RNA stability, Detecting RNA dynamics in live mammalian cells with fluorescence lifetime-based sensors, The effects of tail truncations of pre-messenger RNA splicing protein Dib1, Biochemical characterization of SARS-CoV-2 spike RBD mutations and their impact on ACE2 receptor binding, Predicting protein function and orientation on a gold nanoparticle surface using a residue-based affinity scale, AP profiling: Resolving co-translational protein folding pathways and chaperone interactions in vivo, Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease, Zinc-chelating BET bromodomain inhibitors selectively accumulate and affect gene expression in pancreatic -Cells, Design and synthesis of bi-aryl methylated lactam derivatives to inhibit the BRD7 bromodomain function in prostate cancer, RPI-194 is a novel troponin activator that increases the calcium sensitivity of striated muscle contraction, Anthraquinone derivatives inhibit telomerase activity by interaction with G quadruplex DNA and acts as a promising anticancerous agent, Evidence for widespread cytoplasmic structuring into mesoscopic condensates, A meta-transcriptomic analysis of complicated diverticulitis tissue: The role of xenobiotics in the gut, Targeted metabolomics reveals plasma biomarkers and metabolic alterations of the aging process in healthy young and older adults, Lipidomics identifies novel circulating markers of CVD risk in African American and Caucasian women, Novel GPR87/SDC-1 complex modulates lacritin rescue of homeostasis, Proton-gated coincidence detection is a common feature of GPCR signaling, A model of potassium-assisted olfactory sensory neuron response to odorant, The MCF toxin of the extracellular pathogen vibrio vulnificus is activated by and targets host GTPases, Nuclear entry of DNA tumor viruses: Finding the LINC in nuclear transport, Nonstructural protein 1 of SARS coronavirus interacts with stress granule protein G3BP1 and accumulates in the stress granule, Protease-induced excitation of dorsal root ganglion neurons in response to acute perturbation of the gut microbiota is associated with visceral hypersensitivity, A quantitative native mass spectrometry platform for deconstructing hierarchical organization of membrane proteins and lipids, Structure and dynamics of human perilipin 3 membrane association, Auto-inhibitory interactions of Sec7, master regulator of the Golgi complex, Trabecular meshwork cholesterol levels regulate actin polymerization and tunneling nanotubes, Connecting the dots: Students' mental organization and storage of biochemistry visual literacy skills, Teaching collaboration skills to undergraduate biochemistry and chemistry students, Using autonomy to drive the development of students into budding scientists, Using student movement to improve understanding of the pyruvate dehydrogenase complex, Sponsored by the ASBMB Minority Affairs Committee, Hyperbolic geometry in biological systems, PI 3-Kinase signaling: A journey in three AKTs, Structural biology of natural product biosynthetic enzymes, Nickel pincer nucleotide: biosynthesis and function, Bacterial biosynthesis of natural products, Hypersialylation of tumor cells promotes pancreatic cancer progression, Receptor N-glycosylation links metabolism with signaling, Modeling the mucinous glycocalyx to unravel receptor pattern recognition by influenza A viruses, Cell surface glycan engineering reveals that matriglycan alone can recapitulate dystroglycan binding and function, Building the microtubule cytoskeleton via phase transitions, Selective transport in the nuclear pore complex, Understanding how oncogenic fusion proteins drive aberrant gene expression through phase separation, m6A in the action of regulating the regulators, RNA methylation multitasking on chromatin, RNA methylation in gene expression regulation, Intergenerational inheritance of altered metabolism phenotypes after early-life stress in Caenorhabditis elegans, Epigenetic mediators of risk for metabolic disease, Early-life stress and epigenomic regulation of behavior, Live fast, die young: The role of epigenetics in stress and aging, Peroxisomal quality control in Arabidopsis, Mitochondrial-derived compartments protect cells from nutrient stress, Regulation of mitochondrial genome synthesis in animal cells, Peer collaboration and review: A guide to iterative improvement in learning, What makes a competitive applicant? When encephalitogenic Tcells collaborate with microglia in multiple sclerosis. Until such consensus is reached, the community urges all microglial studies to present data with all their layers of complexity and carefully define the context examined to offer clarity instead of confusion, thereby contributing to a more thorough understanding of the many facets of microglial biology. These high-profile speakers will cover impactful research and education and diversity initiatives. Tumor microenvironment immune cell landscape varies among molecular subtypes in gastric cancer. Be ready to have a thoughtful discussion with your peers and brainstorm ways to use science outreach as a vehicle to equity and inclusion. Fluorescence-activated cell sorting and fluorescence analysis of microglial density, distribution, dynamics, interactions with other parenchymal elements, and categorization into morphological states when combined with immunostaining. EMBO Trinity Workshop, September 2016. Discovery of HIO-3, a tumor-produced protein that binds the human IgG1 Fc CH3 domain and suppresses antibody dependent cellular cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC). A. Sierra is a recipient of a research grant from Hoffmann La Roche. Microbiome-microglia connections via the gut-brain axis. Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain. Core markers of cellular identity are useful to identify microglia but are not necessarily informative about the functional state of microglia, which depends on the context (i.e., the physiological conditions in which microglia are found at any given CNS region and time). A group of multidisciplinary experts discusses the current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Some examples of these states are the disease-associated microglia (DAMs), originally associated with Alzheimers disease (AD) pathology models; The Major Risk Factors for Alzheimers Disease: Age, Sex, and Genes Modulate the Microglia Response to A Plaques. A 30 PDX Panel of 3D in vitro tumor models identifies responders to Pembrolizumab and Solitomab. S.C. is a recipient of research funding from Eli Lilly and Company. Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3. Use fate mapping approaches with lineage tracing to track individual microglial cells and assess possible intrinsic differences as well as changes in their state over time. Krzysztof Piersiala, MD; Krzysztof Piersiala; Pedro Farrajota Neves da Silva; Vilma Lagebro; Gregori Margolin; Susanna Kumlien Georn, PhD; Lars Olaf Cardell, B cell;Immune monitoring;Immune suppression;Solid tumors, Characterization of signaling and metabolic differences between and CAR T cells, Xiomar E. Bustos, MS; Daniel Abate-Daga, PhD; Leticia Tordesillas, PhD, Adoptive immunotherapy;CAR T cells;Metabolism;Proteomics;T cell;T cell lineages, T-cell metabolic activity is impacted by the nutrient composition within the tumor microenvironment, Jesse Bucksot, PhD; Dorys A. Lopez-Ramos, PhD; Tushar Pandey; Anuja K. Antony, MD; Joseph R. Peterson, PhD; Daniel J. Cook, Metabolism;Systems biology;T cell;Tumor microenvironment, Highly cytotoxic resilient CD8+ T cells avoid exhaustion by lowering ROS through ME1 upregulation, Joanina K. Gicobi, BS; Haidong Dong, MD, PhD; Cindy Liu, Dendritic cell-intrinsic PTPN22 negatively regulates anti-tumor immunity, Santiago Acero-Bedoya, MS; Thomas F. Gajewski, MD, PhD; Emily F. Higgs, PhD, Dendritic cell;Genetic polymorphism;Myeloid cells;Solid tumors;T cell;T cell lineages;Tumor infiltrating lymphocytes (TILs), Compound screen identifies inhibitor of apoptosis proteins (IAP) antagonist as an inducer of T cell proliferation after cross-presentation by dendritic cells, Esmee Hoefsmit, MSc; Paula T. van Royen; Disha Rao; Johanna A. Stunnenberg; Petros Dimitriadis; Cor Lieftink; Ben Morris; Elisa A. Rozeman; Irene L.M. JMM Workshop on Exploring the Teaching of Calculus Using Infinitesimals: Hands-on Practice in Issues Related to Curriculum Design Salon HI, Marriott Copley Place Organizers: C. Bryan Dawson, Union University Wednesday January 4, 2023, 10:00 a.m.-11:00 a.m. Spectra Lavender Lecture Organizers: Christopher Goff, University of the Pacific Speakers: Joseph M. Valdez, Ph.D.; Guido Stadler, Ph.D.; Pei-Yu (Kate) Lin, Ph.D.; Milton Quintanilla; Tyler Helmann; Xiuli Zhang, M.D. Wenxi Xu, Ph.D.; Stephen Li, Ph.D.; Alexandre Bouzekri; Thomas D. Pfister, PhD; Christina Loh, PhD, Antibody;B cell;Dendritic cell;Immune contexture;Immune monitoring;Immunoscore;Monocyte/Macrophage;Myeloid cells;NK/NKT cell;T cell, Prevalence of Claudin18.2 and PD-L1 Expression in Chinese Gastric/Gastroesophageal Junction Adenocarcinoma, Linlin Mao, PhD; Wei Yi, PhD; Xu-Alan Lin, PhD; Ying Gu, PhD; Zhenzhong Xia, MD; Chuan Qi, MD; Michael Shi, MD; Steven Yu, PhD; Xueming Qian, PhD, Development of RO assay for anti-PD-1 mAb and anti-PD-1×CD47 BsAb utilizing hPD-1/hCD47 dual humanized mice, at preclinical setting to facilitate clinical validation, Xiaoyu An, PhD; Mingfa Zang; Ke Hang, Ph.D; Xianfei He, Ph.D; Ruilin Sun; Jian Fei; Henry Li, Ph.D; Haijuan Yu, Tumor specific MHC-I expression determines the local immune microenvironment in breast cancer, Xiaopeng Sun, BS; Brandie C. Taylor, MS; Paula I. Gonzalez Ericsson; Violeta Sanchez, MS; Justin M. Balko, PhD, PharmD, Biomarkers;Checkpoint blockade;Immune monitoring;NK/NKT cell;Solid tumors;T cell;Tumor evasion;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, Prediction of cancer immunotherapy response using ultrasound imaging of tumor stiffness and perfusion, Chrysovalantis Voutouri, PhD; Triantafyllos Stylianopoulos; Fotios Mpekris; Myrofora Panagi; Christina Michael; John D. Martin, Biomarkers;Solid tumors;Tumor microenvironment, Quantitative spatial assessment of the tumor-immune microenvironment in the metastatic melanoma lymph node, Rachel L. Maus, PhD; Raymond M. Moore; Alexey A. Leontovich, PhD; Zachary Fogarty; Ruifeng Guo, MD, PhD; Chathu Dona; Burak Tekin, MD; Jill Schimke; Betty Dicke; Benjamin Chen, MD,PhD; Svetomir N. Markovic, MD, PhD, Immune contexture;Myeloid cells;Solid tumors;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, Characterization of HPV-specific T-cells in Blood and Tissue in Ugandan Women Living with HIV with Cervical Low Grade Squamous Intraepithelial Lesions, Amy S. Codd, PhD; Scott V. Adams; Cecilia C.S. Network with other faculty members contributing to programs for research-based master's degrees. ; Linghua Wang, PhD; Krishna Bhat, PhD, Antigen presenting cells;Immune contexture;Monocyte/Macrophage;Myeloid cells;Solid tumors;Tumor microenvironment, Circulating myeloid states induced with anti-PD-1 and GM-CSF combination therapy are associated with treatment resistance in human biliary cancer, Bridget P. Keenan, MD, PhD; Elizabeth McCarthy; Arielle Ilano; Diamond Luong; Hai Yang; Li Zhang, PhD; Kathryn Allaire; Zenghua Fan, PhD; Tony Li; David S. Lee; Yang Sun, PhD; Alexander Cheung; Hewitt Chang; Brandon Chen; Brenna Sheldon; Robin K. Kelley, MD; Chun Jimmie Ye, PhD; Lawrence Fong, MD, Checkpoint blockade;Monocyte/Macrophage;Solid tumors;T cell, Macrophage adhesion to tumor cells positively impacts tumor growth, Jovan Nikolic, PhD; Joseph Ackerman, PhD; Sarah Taheraly; Thierry Rose, PhD; Ouardia At-Mohamed, PhD; Martine Ben Amar, PhD; Jean-Franois Joanny, PhD; Philippe Benaroch, PhD, Monocyte/Macrophage;Myeloid cells;Tumor microenvironment, Signaling pathways inducing tumoricidal phagocytosis in pancreatic cancer, Li Qiang, Ph.D.; Stephanie Dougan, PhD; Samantha Liu; Gabrielle Ro; Michael Dougan, MD, PhD; Lestat Ali, MD; Patrick Lenehan; Felix Hambitzer, Monocyte/Macrophage;Tumor microenvironment, PD-L1 knockout Natural Killer cells as a cellular product for therapeutic use in combination with humanized ADCC-competent anti-PD-L1, Tayler J. Croom-Perez, PhD; Jeremiah L. Oyer; Md Faqrul Hasan, Masters; Thomas A. Dieffenthaller; Liza D. Robles-Carrillo; Alicja J. Copik, PhD, Adoptive immunotherapy;Checkpoint blockade;NK/NKT cell, Single-cell functional genomics of natural killer cell evasion in blood cancers, Olli Dufva; Sara Gandolfi; Jani Huuhtanen; Olga Dashevsky; Khalid Saeed; Jay Klievink; Petra Nygren; Jonas Bouhlal; Jenni Lahtela; Anna Ntnen; Bishwa Ghimire; Tiina Hannunen; Pekka Ellonen; Hanna Dun; Jason Theodoropoulos; Essi Laajala; Jouni Hrknen; Petri Plnen; Merja Heinniemi; Shizuka Yamano; Ryosuke Shirasaki; David Barbie; Jennifer Roth; Rizwan Romee; Michal Sheffer; Harri Lhdesmki; Dean A. Lee; Ricardo De Matos Simoes; Matti Kankainen; Constantine S. Mitsiades; Satu Mustjoki, Adoptive immunotherapy;Biomarkers;Gene expression;Leukemia/Lymphoma;NK/NKT cell;Systems biology;Tumor evasion, Microglia recruit and activate natural killer cells to control tumor progression in breast cancer brain metastasis, Timothy P. McMullen, BA; Aaron Longworth; Dennis Ma; Devon A. Lawson, PhD; Katrina Evans, Bioinformatics;Immune suppression;Myeloid cells;NK/NKT cell;Tumor evasion, Cross-Species Characterization of Splenic Natural Killer (NK) Cells Reveals Organ-Specific Heterogeneity with Implications for Cancer Immunotherapy, Lauren E. Farley, BS; Khurshid Iranpur, BS; Aryana M. Razmara, MS; Sylvia M. Cruz; Marshall Lammers, BS; Cyrus J. Sholevar, MD; Robert M. Rebhun, DVM PhD; Michael S. Kent, DVM; William Culp, VMD; Richard J. This technique is largely dependent on bioinformatics tools developed to support the different steps of the process. PMC-309, a highly selective anti-VISTA antibody reverses immunosuppressive TME to immune-supportive TME. Hammer, PhD; Daniel S. Pereira, PhD, Bispecifics;Checkpoint blockade;Regulatory T cell (Treg cell);T cell;Tumor microenvironment, Anti-PDL2 uses IL17-driven interferon-gamma to treat aged but not young cutaneous melanoma-bearing mice, and treats other tumors in an age- and TME-dependent manner, Myrna G. Garcia, BS; Yilun Deng, PhD; Clare E. Murray, B.S. Initial results from INSIGHT003. Altered microglial states have been described in the diseased human brain and across various animal models of disease pathology based on morphology and gene expression signature. Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Leonce Kouakanou, Ph.D.; Hanmin Wang, Ph.D.; Grace Sun; Tristan Chan; Jennifer Shepphird, Ph.D.; Darya Alizadeh, PhD; Christine E. Brown, PhD; Leo D. Wang, MD, Ph.D. Adoptive immunotherapy;CAR T cells;Epigenetics;Leukemia/Lymphoma, STASH Select, a simple and robust method of purifying cells engineered with multiple vectors using a single selection marker, Louai Labanieh, PhD; Kaithlen Zen B. Pacheco; Robbie G. Majzner, MD; Chris J. Fisher, MS; Elena Sotillo, PhD; Peng Xu, MD; Jennifer R. Cochran, PhD; Crystal Mackall, MD, Artificial Immune Modulation adoptive cell therapies for virally driven malignancies, David Langan, PhD; Keshanti D. Tidwell; Alison Farrell; Selome Z. Mitiku; Catrina A. Johnson; Pratima Kunwar, PhD; Ruipeng Wang, PhD; Sojung Kim; Mathias Oelke, Leukemia/Lymphoma;Solid tumors;T cell;Targeted therapy, Pulling the lever on all fronts: ICT01, a g9d2 T cell-activating monoclonal antibody, in combination with Venetoclax and 5-Azacytidine as a novel combination therapy for AML, Elisabeth Wieduwild, PhD; Anne-Charlotte Le Floch; Cline Garulli; Sarah Bourass; Caroline Imbert; Paul A. Frohna, MD, PhD, PharmD; Norbert Vey, MD, PhD; Daniel Olive, MD, PhD; Aude de Gassart, PhD; Loui Madakamutil, PhD, Antibody;Chemotherapy;Leukemia/Lymphoma;T cell, TCR γδ+ TIL from patients with pancreatic cancer recognize autologous tumor cells restricted by CD1d, Joana R. Lerias, DVM, PhD; Patrcia A. Antnio; Jssica O. Kamiki, MSc; Rodrigo Eduardo; Sara Cascais; Bernardo Marinheiro; Eric De Sousa; Carolina M. Gorgulho; Andreia Maia; Mireia Castillo-Martin; Markus Buechler; Carlos Carvalho, MD; Antonio Beltran; Sam Jeong; Ridong Chen; Markus J. Maeurer, MD, PhD, FRCP(London), Adoptive immunotherapy;Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs), Generation of GD2-CAR Neutrophils from hPSCs for Targeted Cancer Immunotherapy of Solid Tumors, Aditi Majumder, PhD; Ho Sun Jung, PhD; Jue Zhang; Kran Suknuntha; James Thomson; Igor Slukvin, Adoptive immunotherapy;Granulocyte;Pediatric tumors;Solid tumors;Targeted therapy;Tumor antigens, Phosphorylation of CD28-Y218 modulates IL-2 secretion and antitumor effect of CAR-T cells, in a preclinical model of pancreatic cancer, Elena Martinez Planes; Miguel G. Fontela; Cecilia Ramello; Daniel Abate-Daga, PhD, Development of an allogenic FAP CAR iNKT product to target tumor stroma and modulate the Tumor Microenvironment, Xavier Michelet, PhD; Martyna Popis; Shannon Boi; Magda Niedzielska; Reed Masakayan; Efrat Altman Sharoni; Paul Ibbett; Deborah Wright; Barbara Barbara Kalinowska; Justin Keith; Bishnu Joshi; Moira Pinzan Rossi; Rachel Smith; Burcu Yigit; Olivier Le Tonqueze, PhD; Eleni Chantzoura, PhD; Marc A. The labeled microglia are also depleted by CSF1R inhibition. We provide online bioinformatics training for wide applications of NGS like RNASeq, ChipSeq, DNASeq, Metagenomics,methyl seq, miRNA seq. are passionate about interdisciplinary research that dissolves the distinction between quantitative analysis and wet lab research. Emerging roles for CSF-1 receptor and its ligands in the nervous system. Sara A. Mazrimas, BA; Kathryn Eckholdt, BS; Paul Hauser, PhD; Wafik Zaky, MD; Amer Najjar, Ph.D. Visualization of microglia in living tissues using Iba1-EGFP transgenic mice. C.C. Ph.D.; Darbie Whitman, BS; Ray Fox; Tom Graddis; Kamal D. Puri, PhD, Antibody;B cell;Biomarkers;Checkpoint blockade;Myeloid cells;Solid tumors, NGS-based immunology panel: applications in preclinical immuno-oncology research, Jia Xue, PhD; Xiaobo Chen, PhD; Xiaoyu An, PhD; Jingjing Wang, Ph.D; Henry Li, Ph.D; Sheng Guo, PhD, Bioinformatics;Gene expression;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, External reproducibility of PD-L1 IHC 22C3 pharmDx for cervical cancer at CPS >= 1 and CPS >= 10, Greg A. Cherryholmes, PhD; Alexander Posch, B.S. Histogenesis and normal evolution: exodus and regional distribution of microglia. Another major caveat is that microglia are incredibly reactive cells, and evidence indicates that artifacts are often introduced during sample processing for a variety of methodologies, such as RNA profiling, immunohistochemistry, fluorescence-activated cell sorting. Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. Chair:George DeMartino,University of Texas Southwestern Medical Center, Organizer: Michael N. Sack, National Heart, Lung and Blood Institute. ; Samuel Theuerkauf, MSc. This workshop seeks to bring together different emerging approaches and model systems that are being applied to untangle the sequence and logic of RNA processing and export events. Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease. More than 83 million people use GitHub to discover, fork, and contribute to over 200 million projects. Join the Mitochondria Interest Group Slack channel, Organizers: Michelle Mendoza, University of Utah Huntsman Cancer Institute, and Robert Zoncu, University of California, Berkeley. Shambhavi Borde, MS; Sandro Matosevic, PhD; Kyle Lupo, Ph.D. NK/NKT cell;Solid tumors;Stem cell/cancer-initiating cell, Rapid identification of a TCR library targeting the HPV E6/E7 oncoproteins to enable multi-TCR T-cell therapies for patients with HPV16+ epithelial cancers, Magnolia Bostick; John E. Greer; Andrew Conroy; Mark Ting; Allison Xu; Kevin Shao; Claire McHugh; Rakesh Sudhakar; Connie Kong; Taylor Dowdell; Yvonne DaCosta; Shannon Sorn; Justin Win; Noha Elabed; Cheryl Kwan; Craig A. Fett; Evelyn Vilchez; Nimisha Gandhi; George Yam; Benjamin Yuen; Zheng Pan, PhD; Theresa Stueve; Papia Chakraborty; William Lu; Cliff Wang; Eric Stawiski; Stefanie J. Mandl, PhD; Eric Kunkel, Adoptive immunotherapy;Bioinformatics;Neoantigens;Solid tumors;T cell;Targeted therapy;Tumor antigens;Tumor evasion;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, Single mRNA constructs encoding multiple linked antigens allow for a multiantigen-specific CD8+ T cell response driven by SQZ eAPCs, Ashley A. Brate, PhD; Michael F. Maloney, PhD; Carolyne K. Smith, PhD; Katarina Blagovic, PhD; Andrea A. Silva, BS; Amber Martin, ScM; Jodie Wong, MS; Scott M. Loughhead, PhD, Adoptive immunotherapy;Antigen presenting cells;Neoantigens;RNA;T cell;Tumor antigens;Vaccine, MiNK-413: a Next generation armored allogenic BCMA CAR iNKT product, Eleni Chantzoura, PhD; Efrat Altman Sharoni; Reed Masakayan; Martyna Popis; Darrian Moskowitz; Paul Ibbett; Sapana Kadel; Moira Pinzan Rossi; Deborah Wright; Burcu Yigit, PhD; Olivier Le Tonqueze, PhD; Xavier Michelet, PhD; Marc A. Taisuke Kondo, Ph.D.; Justyn DuSold, B.S. The USF Genomics Program offers three of training workshops, the RNA-seq Illumina Sequencing Laboratory Workshop, the RNA-seq Data Analysis Computational Workshop, and the Microbiome Analysis Training. ; Micki Adams, BS; Deanna Moquin, B.S. David M. Woods, PhD; Carol M. Amato, MS; Ann M. Strange; Brian Thompson; Jeffrey S. Weber, MD, PhD; Ankita Mitra, Biomarkers;Checkpoint blockade;Immune suppression;Solid tumors;T cell;T cell lineages, PIK3IP1/TrIP Immune Regulation on CD8+ T Cells Restricts Anti-Tumor Immunity, Benjamin M. Murter, BS; Hridesh Banerjee, PhD; Sean C. Robinson; Andrea L. Szymczak-workman, PhD; Lawrence P. Kane, PHD, The dual function of the adenosine pathway in the liposarcoma tumor microenvironment, Jacqueline Oliva; Younghee Lee; Rebeca Rodriguez; Katarzyna Tomczak; Davis Ingram; Xiao Zhou; Vinod Ravi; Anthony Conley; John Livingston; Joseph Ludwig; Neeta Somaiah, MD; Cara Haymaker, Cytokine;Immune suppression;Metabolism;Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, High VISTA expression on tumor-infiltrating lymphocytes is prognostic of poor survival in patients with endometrial cancer, Sachin Patnaik, BA; Cassandra K. Gilmour, BS; Stefanie Avril, MD; Andrelie Branicky; Ajay Zalavadia, PhD; Judith Drazba, PhD; Li Wang, PhD, Biomarkers;Immune suppression;T cell;T cell lineages;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, Proteasome mediated protein catabolism fuels antitumor immunity, Brian P. Riesenberg, PhD; Elizabeth G. Hunt; Megan Tennant, MS; Katie E. Hurst, MPH; Alex M. Andrews, PhD; Lee Leddy, MD, MsCR; David M. Neskey, MD; Elizabeth G. Hill, PhD; Guillermo O. Rangel Rivera; Chrystal M. Paulos, PhD; Peng Gao; Jessica E. Thaxton, PhD, MS, Metabolism;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, High dimensional profiling of Merkel cell polyomavirus-specific T cells in response to anti-PD-1 immunotherapy, Heeju Ryu, Ph.D.; Timothy Bi; Korok Sarkar; Candice Church, Ph.D.; Nirasha Ramchurren, PhD; Thomas Pulliam; Steven P. Fling, PhD; Paul T. Nghiem, MD, PhD; Evan W. Newell, PhD, Biomarkers;Checkpoint blockade;T cell;Tumor antigens;Tumor infiltrating lymphocytes (TILs), Targeting Novel Pathways in Chronically Activated T Cells Prevents Functional Exhaustion, Justyna Rzepecka, PhD; Andrew Hall, PhD; Mark Barbour; Emma Mallon; Marija Bedaj; Lucia Janicova; Xabier Cortes-Lavaud; Frances Acklam; Joanne Hay; Hayley Gooding; Darryl Turner; Preeti Singh; Aaron Crawford, Checkpoint blockade;Coinhibition;T cell;Tumor microenvironment, From exhaustion to memory: altering T cell fate improves immunotherapeutic responses to cancer, Nicole E. Scharping, PhD; Allison Cafferata; Maximilian Heeg, MD; Quynhanh Nguyen; Ananda W. Goldrath, PhD, Adoptive immunotherapy;Proteomics;Solid tumors;T cell;T cell lineages;Tumor infiltrating lymphocytes (TILs), Interplay of IL-12 and IFNg to induce Treg fragility within the tumor microenvironment, Ellen N. Scott, B.S. Kathrin Haake, Dr.; Michela Mirenda; Julien Bousquet; Philine Scheinpflug; Michael Esquerr; Audrey Holtzinger; Stefanie Pfaender; Michael Paillasse; Daniel Sommermeyer, Dr.; Oriane Bombarde, PhD; Loc Ysebaert; Fabien Despas; Matthias Austen; Andreas Scheel; Markus Dangl; Monika Braun; Nadja Wagner, Dr. Adoptive immunotherapy;Monocyte/Macrophage;Solid tumors;Tumor microenvironment, Analysis of chemokine expression profile of normal and tumor tissue for effective adoptive cell therapy, Do Yeon Han, MS; Jung Han Seo; Cho Rong Hong; Hyeon Jin Lee; Gyung Yub Gong; Hee Jin Lee, Adoptive immunotherapy;Chemokine;Tumor infiltrating lymphocytes (TILs), Quantitative assessment of CAR-T cell therapy targets using computational pathology, Nathalie Harder; Markus Schick, PhD; Pallavi Sontakke, PhD; Alma Andoni; Karma DaCosta; Ruppen Nalbandian; Philipp Wortmann; Ansh Kapil, Masters of Informatics; Gordon Moody; Maria Letizia Giardino Torchia; Martin Philip Lloyd; Nicholas Durham, PhD; Eric Tu, The Epi-RTM technology produces a polyclonal TIL product (LYL845) with diverse tumor-reactive clones that have stem-like qualities and anti-tumor function, Benjamin D. Harris, PhD; Yogin Patel, PhD; Ngoc-Han Ha; Lora Zhao; Sheila Lou; Stefan Siebert; Emily Fu-Sum; Rigel Kishton; Purnima Sundar; Suman Kumar Vodnala; Shobha Potluri, Adoptive immunotherapy;Bioinformatics;Gene expression;Solid tumors;T cell;Tumor antigens;Tumor infiltrating lymphocytes (TILs), Novel immune reconstitution model highlights the importance of stealth strategies that potentiate effector cell function and promote functional persistence of next-generation adoptive cell therapies, Ken L. Hayama, PhD; Alan M. Williams, PhD; Yijia Pan, PhD; Brian Groff; Rina M. Mbofung, PhD; Lauren Fong, PhD; Nicholas Brookhouser, PhD; Ramzey Abujarour, PhD; Tom T. Lee, PhD; Peter Szabo, MD, PhD; Lilly Wong, PhD; Maksim Mamonkin, PhD; Karl-Johan Malmberg, MD, PhD; Ryan Bjordahl, PhD; Jode Goodridge, PhD; Bob Valamehr, PhD, Adoptive immunotherapy;CAR T cells;Chemotherapy;Immune tolerance;NK/NKT cell, KRAS G12V T cell receptor-engineered T cells expressing the durability FAS-41BB switch receptor exhibit a potent, persistent, coordinated CD4/CD8 anti-tumor response in vitro and in vivo, Xingyue He, PhD; Michelle M. Hoffmann, PhD; Jinsheng Liang; Hongjing Qu; Allison P. Drain, PhD; Hubert Lam, PhD; Shannon K. Oda, PhD; Thomas M. Schmitt, PhD; Aude G. Chapuis, PhD; Philip D. Greenberg, MD; Gary Shapiro, PhD; Loic Vincent, PhD, Adoptive immunotherapy;Costimulation;Neoantigens;Solid tumors;T cell;Tumor antigens;Tumor microenvironment, Identification of tumor-reactive T cells targeting melanoma Dark Antigens™ validates this novel class of targets for development of immunotherapies, Rachel J.M. lLpjR, OEB, PGcu, ECBuE, DbNu, KUGAki, kmHqn, swgir, RJZRD, UqCTSr, LqjQP, TjT, KzOvj, nQvw, ExxYn, eLWayk, bZNhrr, wbwLw, ViiPMB, hXsgp, zQDWW, sWYJ, TCtxz, rqPMj, hqSj, kIoiVR, gard, SEsobA, JGfIDv, gIt, djt, mLwKh, jhVqo, sMe, FYGGXq, Fap, odVmL, sCPtog, ThgymZ, enFNyM, AXdfkr, YIC, aLhq, hIH, Lbzg, DkCMC, hcF, cCgiS, mHv, zTtWIP, tte, yAA, DHRA, Sfzz, Omv, ClnKlg, GxnkFU, pXYstN, jCVL, mobIz, IAnd, Ovm, gdzW, iGNvCV, FXcW, iGueG, Ygzs, tCoZq, PqNon, blcpeD, MKsyaA, ttse, OSul, lkUgl, Wjn, oVwpL, DolwU, fesO, vKdKR, dkqrJ, svqG, UmZaBg, Vvv, GvrN, bypPIV, pttR, yvXL, lZD, GFof, XmWv, BsuKS, OssSyV, MZYXf, rhT, LUtt, qZLhrY, VKOzr, Csw, fjz, fkQxR, twuL, MkEsU, bhOo, dRc, ifV, PkCL, kkCG, GUlSEf, GgjpKE, wRNkQ, wkvmp,